With M.2, you can see in the above table that it is no different than other types of SSD devices and are self-contained. It can be used as a boot device as long as the server hardware listed in vSphere HCL has M.2 slots available. M.2 could be a single or dual device. In order to use an M.2 SSD in your desktop PC or laptop, you’ll need a motherboard with M.2 slots. Some motherboards have two or more M.2 slots, allows you to run your SSDs in RAID. Differences Between an M.2 and mSATA SSD Both are high-performance SSDs designed for small devices such as laptops and tablets. The mSATA interface used to provide the smallest form factor for SSDs. However, it is limited by the SATA 3.0 link speed of 6 Gb/s and 1 TB maximum capacity. The X299 Deluxe has a BIOS setting to choose between a U.2 device (I'm not familiar with U.2) and the second M.2 slot. Only one can be active. See page 3-18 in the downloadable English manual. Does that have anything to do with your issue?

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The Problem to Clone M2 SSD

What is M.2 SSD?

Before learning how to clone M.2 SSD to M.2 SSD, you may want to know these information about M.2 SSD.

M.2 SSD (formerly known as Next Generation Form Factor (NGFF) SSDs) are smaller and more suited for modern ultraportable devices (Ultrabooks and tablets) compared to older SATA SSDs as they allow for different module widths and lengths to adjust for different connectors. As a result, M2 SSDs are known for their small size and fast speeds.

Why clone M.2 SSD to larger M.2 SSD?

Generally speaking, many small devices like laptops, Ultrabooks, and tablets use a small capacity M.2 SSD drive as their boot drive and HDDs for storage. Once you have the OS, applications, and games installed, you’ll soon find that the drive has run out of space or has very slow respond. To fix this you will need to clone M.2 SSD to larger M.2 SSD drive, then you will:

• Get more storage space.

• Speed up your system.

• Get shorter boot time.

Best M.2 SSD Cloner - AOMEI Backupper

To clone to M.2 SSD safely, you could try the specialist M.2 SSD cloner in Windows 10, 8, 7, Vista, and XP - AOMEI Backupper Professional - that clones everything (including Windows OS, installed programs, and personal files, etc.) from a M.2 SSD drive to new M.2 SSD without affecting the original OS and data.

Besides, it will clone to M.2 SSD with simple clicks, accelerate the overall performance for the M.2 SSD with SSD Alignment, and ensure it's bootable after clone without any issues.

Please download AOMEI Backupper Professional 30 day free trial and have it a go (Clone features in free trial can only be demonstrated, please upgrade to enjoy):

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How to Clone M.2 SSD to M.2 SSD Easily in Windows 10/8/7?

Here is the step-by-step guide to safely clone M.2 SSD to larger M.2 SSD in Windows 10/8/7:

M.2 Slot Desktop

✤✤Before cloning M.2 SSD to larger M.2 SSD, do the following✤✤:
☂Make sure that the new larger M.2 SSD is compatible with your motherboard, or consult your computer manufacturer.
☂Install the larger M.2 SSD correctly. Please disconnect battery or cut off the power supply before installing.
>> On a laptop, open M.2 slot, slide and fix the SSD.
>> On a desktop, open the host cover, find the M.2 connector (labeled with SATA/PCIe), and install the SSD.
☂Prepare an M.2 to USB adapter to connect the larger M.2 SSD with machine if there is only one M.2 slot on your computer.
☂Initial the M.2 SSD in Disk Management and format with MBR or GPT partition style according to your demands.

Step 1. Perform this M.2 SSD cloner after installation, select Clone > Disk Clone. Click System Clone to move operating system only to another M.2 SSD if you prefer.

Step 2. Select the M.2 SSD system disk as the source disk and hit Next to continue.

Step 3. Choose the larger M.2 SSD as the target disk, and then press Next to continue.

★Tips: If there is any data on the destination M.2 disk, it will be erased during the cloning process. Please backup files before the M.2 SSD cloning.

Step 4. Tick SSD Alignment to speed up for M.2 SSD, and then press Start Clone to safely clone M.2 SSD to larger M.2 SSD in Windows 10/8/7.

Usually, this only take a short amount of time, but the larger the disk is, the longer time will be. Because the cloning time depends on the data size of the source m.2 drive.

★Helpful Tips:
1. Sector by sector clone: It enables you to clone all the sectors (blocks) on the source M.2 SSD even it’s blank or bad sector, and much longer time will spend. Uncheck this option will skip the bad sectors if there exists.
2. You could click on Edit Partitions to resize the partitions on the destination disk and you could fully use the storage space on the larger M.2 SSD. There are three options that you may need:
✍Copy without resizing partitions: it’s selected by default. There will be an unallocated space available after cloning smaller disk to larger disk if this option checked. Then, you could merge unallocated space to C drive or other existing partitions, or even create a new partition to store data separately.
✍Add unused space to all partitions.
✍Manually adjust partition size.
If you would like to adjust the partition size automatically during the cloning process, please select the second option or third option.

How to Boot from Cloned Larger M.2 SSD?

After the cloning process has finished, to boot from the cloned larger M.2 SSD correctly, do the following:

• For the computer that only one M.2 slot: shut down your computer, remove the old M.2 SSD, and replace with the newly cloned larger M.2 SSD, boot from the cloned M.2 SSD.

• For the computer that has more than one M.2 slot: Restart your computer and repeatedly press a certain key (usually F2, F10, F12, ESC, DEL, etc.) to enter BIOS or UEFI BIOS, change boot priority to the cloned larger M.2 drive.

M.2 Slot Devices Definition

Remember to replace the mounting screws to secure the M.2 SSD drive in your machine.

Now you have mastered cloning M.2 SSD to M.2 SSD, you might want to try cloning a larger HDD to smaller SSD, make sure the smaller SSD can hold all the data from the larger HDD, cloning a specific partition to the target disk using the Partition Clonefunction, or even cloning MBR disk to GPT disk, or vice versa.

Another secure way to perform M.2 SSD to M.2 SSD migration when there is only one M.2 slot is that backup M.2 SSD, replace smaller M.2 SSD with larger one, and then restore image to the larger M.2 SSD. AOMEI Backupper Professional could do the same task. For detailed steps, please refer to how to upgrade laptop drive via backup and restore.

M.2 Slot Devices Vs

Summing Up

To clone M.2 SSD to M.2 SSD safely, you need to first check that the new M.2 SSD drive is compatible with your motherboard and carefully install the drive correctly. Next, use powerful M.2 cloner like AOMEI Backupper Professional to clone the disk ensuring that it will boot without any issues.

If you are using Windows Server 2003, 2008, 2012, 2016, 2019 (including R2), SBS 2003, 2008, 2011, please try AOMEI Backupper Server and follow the same steps above, and more advanced features provided, command line backup/restore/clone, universal restore, real time file sync, etc.